I have Parkinson's Disease. I've had it for nearly 20 years. For the first 15 or so it wasn't bad -- in fact, entire days would pass when I could almost forget I had it. But though individual days would pass unremarkably, individual weeks would not. Nor would months, or years. I was lucky enough to get in on the ground floor of a new surgical treatment: DBS (Deep Brain Stimulation). It's basically a pacemaker for the brain. It slowed the progress of the disease dramatically.
But it didn't stop it.
Because there's no cure.
That's because it's not a disease, as we currently define it; that is, it doesn't seem pathological in origin. A more suitable qualifier would be "Syndrome". But, though I'm uncertain of the terminology, I can describe what it's like. It's like being dipped in extremely slow-hardening cement. It's hard to get around much, unless I swallow a pharmacy's weight in pills every day. (Which aren't free, even with Medicare.) PD has also pretty much completely destroyed my ability to speak coherently. I can communicate sometimes, although most people aren't fluent in Village Idiot. (In fact, people are usually more fluent in Klingon.) It's become nearly impossible to type anymore. I used to be able to type over 100 wpm; now I'm lucky if I can do ten.
I've had over 400 TV scripts produced, and a half dozen movies; I've had 2 dozen novels published and a codswallop or two of comic books, graphic novels, and short stories. I've won an Emmy and been nominated for several more awards, including a Hugo and a Nebula. Yet whenever I go out in public people watch me like they expect me to start flinging my filth like a bored primate at the City Zoo.
If I had to pick one thing that I'd like to have changed about this motherfucking disease (please excuse my language; I meant to say motherfucking syndrome), it's my inability to speak. It's the result of a confluence of factors; a sub-syndrome of the larger one. As such, it can be possibly addressed symptomatically, which is a fairly arduous "two-steps-forward-one-step-back" process, or I can try to find a wholly different paradigm to address it through.
Which I may have done; theoretically, at least. I'm not prepared to say anything further at the moment -- but fingers crossed.